Milk and Dairy Products

Title Predicting sensory evaluation indices of Cheddar cheese texture by fluorescence fingerprint measurement coupled with an optical fibre
Author A.Chiba, M.Kokawa*1, M.Tsuta*2, and S.Todoriki*1,2
*1Faculty of Life and Environmental Sciences, University of Tsukuba, *2Food Research Institute, National Agriculture and Food Research Organisation
Journal International Dairy Journal 91: 129-136 (2019)
Summary A fluorescence fingerprint (FF) was used to develop a quick and non-contact practical method for predicting the sensory evaluation index of cheese texture (cheese body measurements). A partial least squares model was constructed from FF data and cheese body measurements of Cheddar cheeses. The cheese body measurement was successfully predicted by the PLS model with a coefficient of determination for calibration of 0.800.
Title Effects of manufacturing conditions on the foaming properties of milk and sensory characteristics of foamed milk
Author S.Hatakeyama, M.Akiyama, R.Yoneyama, K.Watanabe, R.Koizumi, K.Miyaji, Y.Mizota, M.Ikeda, and S.Wakao
Journal LWT Food Science and Technology, 99: 555-561(2019)
Summary This study showed that different manufacturing conditions of milk had significant effects on the foaming properties and sensory characteristics of foamed milk. The foaming properties were investigated using a Dynamic Foam Analyzer 100 and the sensory characteristics of foamed milk were evaluated by descriptive analysis by means of a trained panel.
Title Effects of homogenization pressure on sensory characteristics, preference and flavor release of flavored dairy beverages
Author T.Kawaguchi
Journal Journal of Japan Asssociation on Odor Environment 50(2): 130-137(2019) 
Summary Homogenization pressure for producing milk or dairy beverages was investigated to affect significantly on these sensory characteristics, preference and flavor release by sensory evaluation and gas chromatography-mass spectrometry (GC-MS) analysis using a retronasal aroma simulator (RAS).
Title Effects of manufacturing processing conditions on retronasal-aroma odorants from a milk coffee drink
Author M.Ikeda, M.Akiyama, Y.Hirano, K.Miyaji, Y.Sugawara*1, Y.Imayoshi*1, H.Iwabuchi*1, T.Onodera*2, and K.Toko*2
*1San‐Ei Gen F.F.I., Inc., *2Kyusyu Univ.
Journal Journal of Food Science 83(11): 2733-2744 (2018)
Summary From GC-O analysis of the retronasal-aroma odorants from a milk coffee drink, it is revealed that the new manufacturing process without pH adjustment of coffee is superior to the conventional process with pH adjustment in retaining the coffee original aroma.
Title Changes in odor compounds of a Lactobacillus-fermented dairy beverage during two weeks of refrigerated storage
Author M.Akiyama, T.Suzuki, Y.Murakami*, M.Onishi*, Y.Mizota, K.Miyaji, M.Ikeda, and H.Iwabuchi*
*San-Ei Gen F.F.I., Inc.,
Journal Food Science and Technology Research, 24 (6): 1129-1137 (2018)
Summary Lactobacillus paracasei MCC1849 (LP) has the potential to modulate immune function. Changes in odor compounds of a functional LP-fermented dairy beverage during two weeks of refrigerated storage were analyzed by gas chromatography-olfactometry. Thirty-four odorants were detected, of which 29 were identified. 4-(4’-Hydroxyphenyl)-2-butanone (raspberry ketone) was firstly identified as an odorant in fermented dairy products.
Title Effects of Processing Conditions During Manufacture on Retronasal-Aroma Compounds from a Milk Coffee Drink
Author M.Ikeda, M.Akiyama, Y.Hirano, K.Miyazi, M.Kono*1, Y.Imayoshi*1, H.Iwabuchi*1, T.Onodera*2, and K.Toko*2
*1 San-Ei Gen F.F.I., Inc., *2Kyushu Univ.
Journal Journal of Food Science 83(3): 605-616 (2018)
Summary Regarding the manufacture of a ready-to-drink (RTD) milk coffee that retained original volatile characteristics, an investigation of retronasal-aroma compounds from an RTD milk coffee revealed that a new process without pH adjustment of coffee was superior to a conventional process with the pH adjustment.


Title Potential Role of Amino Acid/Protein Nutrition and Exercise in Serum Albumin Redox State
Author Y.Wada, Y.Takeda, and M.Kuwahata*
*Departments of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
Journal Nutrients, 10(1), Art.17 (2018)
Summary This article extensively reviews serum albumin and the redox state of albumin in the context of amino acid/protein nutritional status and exercise training.

Bifidobacteria and Intestinal Flora

Title Impact of a bathing tradition on shared gut microbe among Japanese families
Author T.Odamaki, F.Bottacini*, E.Mitsuyama, K.Yoshida, K.Kato, JZ.Xiao, and D.van Sinderen*
*APC Microbiome Ireland and School of Microbiology, National University of Ireland
Journal Scientific Reports 9(1): Art.No. 4380 (2019)
Summary Sharing of Bifidobacterium longum strains had recently been shown to occur among Japanese family members, a phenomenon that is not confined to mother-infant pairs. In the current study, we investigated if bathtub water is a possible vehicle for the exchange of strains as a consequence of a Japanese custom to share bathtub water by family members during bathing practices. Viable bifidobacterial strains were isolated from all bathtub water samples. We showed that the fecal microbiota composition among family members that share bathtub water is significantly closer than that between family members that do not engage in this practice. Our results indicate that bathtub water represents a vehicle for the transmission of gut bacteria, and that the Japanese custom of sharing bathtub water contributes to the exchange of gut microbes, in particular bifidobacteria, among family members.
Title Bifidobacterium breve A1 supplementation improved cognitive decline in older adults with mild cognitive impairment: an open-label, single-arm study
Author Y.Kobayashi, T.Kinoshita*1, A.Matsumoto*2, K.Yoshino*2, I.Saito*1, and JZ.Xiao
*1Ehime Univ. *2Aki Orthopedic Rehabilitation Clinic
Journal The Journal of Prevention of Alzheimer's Disease 6(1):70-75 (2019)
Summary We conducted an open-label, single-arm study to examine the effects of 24-week supplementation of B. breve A1 on 19 elderly with mild cognitive impairment(MCI). The study showed that oral supplementation of B. breve A1 in participants with MCI improved cognitive function.
Title Association between functional lactase variants and a high abundance of Bifidobacterium in the gut of healthy Japanese people
Author K.Kato, S.Ishida*, M.Tanaka*, E.Matsuyama, Jz.Xiao, and T.Odamaki
*1Business Planning Group, Next Generation Science Institute, DeNA Life Science, Inc., *2RandD Group, DeNA Life Science, Inc.
Journal PLoS ONE 13(10), e0206189(2018)
Summary We investigated the possible contribution of functional lactase loci to the high abundance of Bifidobacterium in Japanese populations. The results indicated low lactase activity in Japanese people and possible contribution of host genetic variation-associated low lactase activity to the high abundance of Bifidobacterium in the Japanese population.
Title Breast milk on the infant faecal microbiome: Components of breast milk orchestrating the establishment of bifidobacteria species.
Author C.B.Wong and Jz.Xiao
Journal Journal of Human Nutrition & Food Science 6(2): 1123 (2018)
Summary In this review, we introduced the reason why only human bifidobacteria proliferate in the intestine of babies, focusing on their compatibility with oligosaccharides and lysozyme in breast milk.
Title Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults
Author M.Murata, J.Kondo*1, N.Iwabuchi, S.Takahashi, K.Yamauchi, F.Abe, and K.Miura*2
*1 Department of Food and Nutrition, Higashi Chikushi Junior College, *2 Department of Nutrition, Faculty of Home Economics, Kyushu Women’s University
Journal Beneficial Microbes 9 (6): 855-864 (2018)
Summary The effects of heat-killed Lactobacillus paracasei MCC1849 (LAC-Shield™) on the common cold and mood states during winter in healthy adults were evaluated in a randomised, double-blind, placebo-controlled trial. In a subgroup of subjects susceptible to the common cold, the incidence and symptom scores of the common cold significantly improved in the 10 billion cell MCC1849-intake group. The results of this study indicate that paraprobiotic L. paracasei MCC1849 has the potential to improve resistance to common cold infections and maintain a desirable mood state, even under mental stress conditions.
Title Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: A randomized, double-blind, placebo-controlled trial
Author J.Minami, N.Iwabuchi, M.Tanaka, K.Yamauchi, J.Xiao, F.Abe, and N.Sakane* *National Hospital Organization Kyoto Medical Center
Journal Bioscience of Microbiota, Food and Health 37(3): 67-75(2018)
Summary The effects of the consumption of Bifidobacterium breve B-3 on body fat reduction in healthy pre-obese (25 ≤ BMI < 30) adults were investigated in a double-blind, placebo-controlled trial. Body fat mass was significantly lower in the B-3 group than in the placebo group. Waist circumference in the B-3 group was significantly lower at week 12 than at the baseline.
Title Genomic diversity and distribution of Bifidobacterium longum subsp. longum across the human lifespan
Author T.Odamaki, F.Bottacini*, K.Kato, E.Mitsuyama, K.Yoshida, A.Horigome, JZ.Xiao, and D.van Sinderen*
*APC Microbiome Institute and School of Microbiology, National University of Ireland
Journal Scientific Reports 8(1): Art. 85 (2018)
Summary We performed a comparative genome analysis of Bifidobacterium longum subsp. longum to unravel the reason why this subspecies are widely distributed across all generation. As results, a broad distribution of them across the human lifespan is due to a high transfer level between family members. We furthermore identified a variety of genes which could enhance their adaptation and increase competitiveness in the gut environment, enriched in genomes corresponding to specific ages.
Title Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease
Author Y.Kobayashi, H.Sugahara, K.Shimada*1, E.Mitsuyama, T.Kuhara, A.Yasuoka*1, T.Kondo*1, K.Abe*1,2 and JZ.Xiao
*1Group for Food Functionality Assessment, Kanagawa Institute of Industrial Science and Technology, *2Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Journal Scientific Reports 7(1):13510 (2017)
Summary We focused on gut-microbiota-brain axis and found that oral administration of Bifidobacterium breve A1 to Alzheimer's disease model mice improved cognitive dysfunction through suppressing the expression of inflammation and immune-reactive genes.


Title Effect of overhead irrigation with slightly acidic hypochlorous acid water on reducing anthracnose infection of Cultivars Kirapika and Benihoppe strawberry seedlings
Author T.Nakamura, T.Ikari*, M.Tanaka, K.Yamauchi, and F.Abe
*Shizuoka Prefectural Research Institute of Agriculture and Forestry
Journal Annual Report of the Kanto-Tosan Plant Protection Society, No. 65 pp.32-34 (2018)
Summary Use of slightly acidic hypochlorous acid water (PURESTER-generated water) to irrigate strawberry seedlings revealed that it had an effect for reducing infection with anthracnose, a major disease with a strong bearing on cultivation. In addition, because there was no detectable adverse influence on growth, it is thought that slightly acidic hypochlorous acid water could be effectively used for irrigation of strawberry seedlings.

Functional Ingredients

Title Casein materials show different digestion patterns using an in vitro gastrointestinal model and different release of glucagon-like peptide-1 by enteroendocrine GLUTag cells
Author Y.Komatsu, Y.Wada, H.Izumi, T.Shimizu, Y.Takeda, T.Hira*, and H.Hara*
*Research Faculty of Agriculture, Hokkaido University
Journal Food Chemistry 277: 423-431 (2019)
Summary We compared protein digestibility and glucagon-like peptide-1 (GLP-1) -releasing activities of micellar casein concentrate (MCC) and sodium caseinate (SCN). The digestibility of MCC was higher than that of SCN. A comparison of GLP-1-releasing activities showed that MCC induced GLP-1 secretion to a greater extent than SCN.
Title Investigation of potent odorants generated during the production
Author H.Nakada, M.Ohata*1,2, M.Hosaka*1, H.Ochi, F.Abe, and K.Arihara*1
*1Kitasato University, *2Nihon University
Journal Animal Science Journal 89(9):1348-1354(2018)
Summary We evaluated predominant odorants of Whey protein hydrolysates(WPH), and our results showed that difference of odor characteristics between whey protein concentrate(WPC) and WPH, and three odor-active compounds contributed to the odor of WPH. Additionally, this study suggests that specific free amino acids are important precursors for generation of these compounds in manufacturing process of WPH.
Title Antihypertensive effect of the casein-derived peptide Met-Lys-Pro in individuals with high-normal blood pressure or grade 1 hypertension-A randomized, double-blind, placebo-controlled, parallel-group trial-
Author N.Yuda, M.Tanaka, A.Yamada, D.Ochi, K.Yamauchi, F.Abe, and N.Sakane*
*National Hospital Organization Kyoto Medical Center
Journal Japan Pharmacology & Therapeutics 46(4):529-37(2018)
Summary Antihypertensive effect of the casein-derived peptide Met-Lys-Pro (MKP) was confirmed by clinical trial. Daily MKP ingestion is a effective systolic blood pressure lowering treatment for people with mildly high blood pressure.
Title Phytosterols derived from Aloe Vera (Aloe sterol) supplementation prevents skin photoaging acceration by estrogen deficiency.
Author M.Saito, Z.Yao, M.Tanaka, E.Misawa, K.Yamauchi, and F.Abe
Journal FRAGRANCE JOURNAL 45(12): 29-36 (2017)
Summary We have showed that Aloe sterol improving skin dryness in a clinical trial and the anti-photoaging effect in estrogen deficiency model. This review described these results and the usefulness of Aloe sterol supplementation for skin beauty.
Title Blood pressure-lowering effects of casein-derived peptide met-lys-pro in subjects with high-normal blood pressure and grade 1 hypertension - A randomized, double-blind, placebo-controlled, parallel-group, trial-
Author D.Ochi, A.Yamada, K.Yamauchi, F.Abe, and Y.Tho*
*Aiwa Clinic, Latvia
Journal Japanese pharmacology & therapeutics 45(10): 1637-1648 (2017)
Summary We evaluated the effect of Met-Lys-Pro(MKP) in lowering blood pressure in subjects with high-normal blood pressure and grade 1 hypertension in a randomized, double-blind, placebo-controlled, parallel-group trial for 12 weeks.
The result showed that 100 μg MKP has a beneficial effect on lowering systolic and diastolic blood pressure.
Title Effects of lactoferrin and lactoperoxidase-containing food on the oral microbiota of older individuals
Author M.Nakano, H.Wakabayashi, H.Sugahara, T.Odamaki, K.Yamauchi, F.Abe, JZ.Xiao, K.Murakami*, K.Ishikawa*, and S.Hironaka*
*Department of Special Needs Dentistry, Division of Hygiene and Oral Health, Showa University School of Dentistry
Journal Microbiology and Immunology 61(10): 416-426 (2017)
Summary The long-term ingestion of lactoferrin and lactoperoxidase-containing tablets promotes a shift from a gram-negative-dominated unhealthy community to a gram-positive-dominated healthy community in the oral microbiota.